Karyopharm Therapeutics Inc.

NasdaqGS: KPTI · Healthcare

Positivity Index

#6,368 / 6,775

Global

#3,640 / 4,000

United States

Positivity Score

-17,579

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PosiRed: no active red flags · PosiYellow: 1 yellow flag (7/10 points) View flag history →

PosiYellow · yellow flag (stress signal)

Debt obligation accelerated (8-K Item 2.04)

The company reported a triggering event that accelerates or increases a debt obligation in a Form 8-K (Item 2.04) filed on 11 Sep 2026, for example lenders becoming able to demand early repayment.

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Karyopharm Therapeutics Inc. — Overview & Financial Snapshot

Karyopharm Therapeutics Inc. (NasdaqGS: KPTI) is a Healthcare company, ranked #6,368 of 6,775 companies globally and #3,640 of 4,000 in United States on PositoAI, with a Positivity Score of -17,579. Its market capitalisation is ₹116.92 Cr ($12.39M), P/E ratio is -0.0 and P/B ratio is -0.04. It has no active red flags (PosiRed) and 1 yellow flag (PosiYellow, 7/10 points): Debt obligation accelerated (8-K Item 2.04).

For financial statements, ratio trends and score history, Go Deep →

What does Karyopharm Therapeutics Inc. do?

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor…

What is Karyopharm Therapeutics Inc.'s P/E and P/B ratio?

Karyopharm Therapeutics Inc. has a P/E ratio of -0.0 and a P/B ratio of -0.04.

What is Karyopharm Therapeutics Inc.'s debt-to-equity ratio?

Karyopharm Therapeutics Inc. has a debt-to-equity ratio of -0.80.

How much does Karyopharm Therapeutics Inc. owe compared with what it owns?

Karyopharm Therapeutics Inc. owes $3.97 for every $1 it owns (balance sheet Jun 2026), which means it owes more than it owns.

What is Karyopharm Therapeutics Inc.'s Positivity rank?

Karyopharm Therapeutics Inc. is ranked #6,368 of 6,775 companies globally and #3,640 of 4,000 in United States on PositoAI, with a Positivity Score of -17,579.

Does Karyopharm Therapeutics Inc. have any regulatory orders, red flags (PosiRed) or yellow flags (PosiYellow)?

Karyopharm Therapeutics Inc. has no active red flags. It has 1 yellow flag (PosiYellow stress signals, 7/10 points): Debt obligation accelerated (8-K Item 2.04).

Where can I read the latest news about Karyopharm Therapeutics Inc.?

Recent headlines about Karyopharm Therapeutics Inc. from the last 30 days, with links to the original articles, are on its News page on PositoAI.

Does Karyopharm Therapeutics Inc. have a PositoAI PosiShot or QR code?

Yes. A dated PosiShot of Karyopharm Therapeutics Inc.'s current position, a PosiQR code for its live profile and a ready-made dated mention are available on its For this company page on PositoAI.